Christian McCaffrey Injury Concerns Loom Over 49ers Ahead of Key Showdown with Titans
As the San Francisco 49ers emerge from their bye week, they prepare to face the struggling Tennessee Titans, who currently hold a 2-11 record. The Titans managed to secure their second victory last week, buoyed by a standout performance from running back Tony Pollard, who tallied 161 rushing yards. The strategic focus for the 49ers will be to establish an early lead, compelling Tennessee to abandon their ground game.
Injury Woes for McCaffrey
The 49ers’ offensive lineup faces uncertainty with Christian McCaffrey listed as questionable due to a back injury sustained during practice on Thursday. Should McCaffrey be sidelined, expect Brian Robinson to step into a more prominent role on the ground. However, Robinson has only recorded seven receptions for 19 yards this season, which raises questions about the passing attack’s effectiveness. Quarterback Brock Purdy may need to lean heavily on reliable targets like George Kittle and Jauan Jennings to maintain offensive momentum.
A critical storyline will be the performance of Ricky Pearsall, who has struggled recently, posting just five catches for 20 yards over his last three outings. Purdy will face a Titans defense currently ranked 26th in the league, noted for their inability to create turnovers with only six interceptions thus far. Defensive tackle Jeffery Simmons is having a standout season, boasting eight sacks, while linebacker Cedric Gray leads the team in tackles.
The Titans’ defense shows vulnerabilities, particularly against pre-snap motion, and they rank poorly in red zone touchdown percentage (26th) and in wide receiver passing yards allowed (27th). The 49ers will aim to capitalize on these weaknesses, especially on their opening scripted drives, as they seek to convert red zone opportunities efficiently. Notably, Tennessee has not won back-to-back games in over three years, adding pressure to their performance.
Titans Look to Capitalize on Ground Game
On the other side of the field, the Titans will look to replicate their recent success on the ground. Pollard’s impressive outing last week included two touchdowns against the Cleveland Browns, although he faced difficulties in the playoffs against the 49ers earlier this year, where he was limited to just 33 total yards due to an ankle injury. The Titans committed to the run game against Cleveland, giving Pollard 25 carries, and the 49ers will need to focus on tackling fundamentals to contain him, particularly after he broke off a 65-yard run last week.
Tennessee’s quarterback, Cam Ward, currently carries the unenviable title of being the most sacked quarterback in the league, averaging 4.4 sacks per game. With the Titans starting a backup center, the offensive line may be susceptible to pressure from the 49ers’ defensive front. The Titans possess two capable tight ends, Chig Okonkwo and Gunnar Helm, with Okonkwo serving as the leading receiver, tallying 41 receptions for 426 yards, primarily through yards after catch, though he has yet to find the end zone.
Leading wide receiver Elic Ayomanor has had a mixed season, catching less than half of his targets with 30 receptions on 67 attempts for 353 yards and three touchdowns. However, Ward’s accuracy has been improving, exceeding 62% in his last six games. While he can scramble, he prefers to stay in the pocket, having rushed 30 times for 127 yards with a long of 20 yards.
Adding another layer of complexity, rookie Chimere Dike is making waves as the league’s top kick returner, boasting two punt return touchdowns and over 1,300 yards in kickoff returns. The 49ers’ kick coverage unit must remain disciplined to prevent Dike from making impactful plays.
Setting the Stage for a Pivotal Matchup
The 49ers have been unpredictable this season, often defying expectations in critical matchups. This game presents a clear objective: build an early lead and force Ward to operate behind a beleaguered offensive line. Although the 49ers rank last in sacks, they will face an opportunity against a Titans team that has allowed Ward to be sacked 49 times.
With Kittle likely to receive increased targets and Robinson positioned for goal-line opportunities against Tennessee’s vulnerable red zone defense, the 49ers will need to implement a strategy focused on stopping Pollard. Defensive coordinator Robert Saleh is expected to stack the box and emphasize sound tackling and swarm tackling techniques.
The Titans will look to control the clock and maintain their ground game, with Dike posing a legitimate threat in the return game. It will be crucial for the 49ers to limit Ward and Pollard’s effectiveness to avoid a tightly contested game. While it’s anticipated that the 49ers will gain the upper hand, Tennessee’s commitment to the run could keep the contest competitive.
Final Score Prediction: 49ers 27, Titans 17

